Finding the middle ground: how kinetochores power chromosome congression
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چکیده
منابع مشابه
Glucocorticoid receptors: finding the middle ground.
Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as primers of the immune system. Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and funct...
متن کاملGlucocorticoid receptors : finding the middle ground
Introduction Glucocorticoids (GCs) are steroid hormones that are derived from cholesterol and secreted by the zona fasciculata of the adrenal glands. GC production occurs in a circadianand stress-associated manner and is regulated by the hypothalamic-pituitary-adrenal (HPA) axis (1–3). Various physiologic processes, including glucose metabolism and metabolic functions in fat, muscle, and bone, ...
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Background: Saliva of blood-sucking arthropods contains a cocktail of antihemostatic agents and immunomodulators that help blood feeding. Mosquitoes additionally feed on sugar meals and have specialized regions of their glands containing glycosidases and antimicrobials that might help control bacterial growth in the ingested meals. To expand our knowledge on the salivary cocktail of Ædes ægypti...
متن کاملSmall GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.
Rab5 is a small GTPase known to regulate vesicular trafficking during interphase. Here, we show that Rab5 also plays an unexpected role during mitotic progression. RNAi-mediated silencing of Rab5 caused defects in chromosome congression and extensive prometaphase delay, and it correlated with a severe reduction in the localization of the centromere-associated protein CENP-F to kinetochores. CEN...
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To establish sophisticated dialogue systems, text planning needs to cope with congruent as well as incongruent interlocutor interests as given in everyday dialogues. Little attention has been given to this topic in text planning in contrast to dialogues that are fully aligned with anticipated user interests. When considering dialogues with congruent and incongruent interlocutor interests, dialo...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2010
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-010-0321-y